1957-1971

In 1957, the Vitamin and Hormones Plant was incorporated into the structure of the newly established Organic Synthesis Institute (OSI), establishing the Latvian Academy of Sciences (LAS) Organic Synthesis Institute’s Experimental Plant.

The OSI’s manufacture of synthetic medicines was commenced under the leadership of the Institute’s founder, LAS academic, Professor Solomons Hillers (1915-1975). The Plant developed as the OSI’s experimental base for the implementation of fundamental research and scientific innovations in manufacturing.

By the end of the 1950’s, the manufacture of the first chemical products had begun in co-operation with the OSI’s employees - fenilin, furazolidon, furadonin and TioTEFA. In accordance with the areas of research covered by the newly established, serious work begins on the development of anti-cancer agents.

Also under consideration at the same time as the manufacture of ingredients for medical treatment was the manufacture of forms of final dosage formulations and a circuit for tablets was established at the chemical workshop.

There is a gradual transition to the development of new synthetic drug manufacturing technologies as well as the manufacture of such medicines. In 1964, the first chemical synthesis of the anti-cancer product’s active ingredients – Ftorafur – is carried out. Ftorafur is considered to be the biggest success in terms of the collaboration between the Institute and the Plant. The inventors of the synthesis were Regīna Žuka, Marģers Līdaka and Solomons Hillers. The manufacturing technology for the drug was developed at the Plant in 1966.

The first half of the 1960’s was notable for the sharp growth in the total volume of chemical products. The development and manufacture of psychopharmacological medicines was commenced, which even now still remain within «Grindeks»’ sphere of interest.

In 1965, the plant shifted to the exclusive manufacture of organic synthetic products. In total, around 30 different medicines and related technologies were invented during the 1960’s. And subsequently the manufacture of these medicines began.

During the second of the 1960’s, research into peptide chemistry was expanded at the Organic Synthesis Institute. With the branching out of the areas of research, the need arose for the OSI to improve and expand the Experimental Plant. In 1967, the construction of a new block of buildings commenced at Krustpils iela 53 which is still the current location of the «Grindeks» plant and administrative building.