500 mg capsules N60

500 mg capsules
The active substance is 3-(2,2,2-trimethylhydrazinium)
propionate dihydrate.
Antiischaemic agent of a metabolic action

Each capsule contains 500 mg of 3-(2,2,2-trimethylhydrazinium)propionate dihydrate.
The other ingredients are potato starch, silicon dioxide, calcium stearate. Gelatine capsule composition: titanium dioxide, E171, gelatine.

10 capsules per blister. 2 or 6 blisters in a cardboard box.

WHAT MILDRONATE IS AND WHAT IT IS USED FOR

3-(2,2,2-trimethylhydrazinium)propionate dihydrate (Mildronate) is astructural analogue of a precursor of carnitine — gamma-butyrobetaine(GBB). Mildronate inhibits the activity ofgamma-butyrobetain-hydroxylase, causing a decrease of carnitinebiosynthesis and long-chain fatty acids transport through cellmembranes. It prevents the accumulation of Acyl-CoA and Acyl-carnitine,the metabolites of long-chain fatty acids in cells, thus diminishingtheir adverse effects.
Under the conditions of ischemia, Mildronateactivates the anaerobic glycolysis and stimulates the ATP production,and transport, restores the balance between oxygen delivery andconsumption.

Decrease of carnitine concentration results inactivation of synthesis of gamma-butyrobetaine, which possessvasodilatating activity.

Mildronate exerts cardio protectiveeffect. In the case of chronic congestive heart failure it augmentsmyocardial contractility, increases the tolerance of the organism tophysical overload. In patients with II—III stage stable angina pectorisMildronate increases the physical capacity and decreases the number ofangina pectoris attacks.
In the cases of acute and chronic ischemiccerebrovascular disturbances Mildronate ameliorates cerebral blood flowin the ischemic region, promoting redistribution of blood flow infavour of ischemic zone.
Mildronate is also characterised by a toniceffect. It prevents functional disturbances of somatic and vegetativenervous system.

Indications. Cardiovasculardiseases: chronic coronary heart disease, stable angina pectoris,chronic heart failure, functional cardiovascular disturbances,cardiomyopathy.
Acute and chronic ischemic cerebrovascular disturbances.
Mildronateis used also in the cases of decreased performance, physical and psychoemotional overload, and during recovery process.

BEFORE YOU USE MILDRONATE

Do not take Mildronate: if you are hypersensitive to Mildronate or any of the other ingredients of the medicine.

You must tell your doctor before taking your medicine, if:
· you are pregnant or intend to become pregnant;
· are breast feeding.

Special care with Mildronate: Mildronate should be used with caution in patients with chronic liver or kidney diseases during long term therapy.
Safety of Mildronate application in children less than 12 years age was not studied.

Pregnancy: Noclinical data are available on the drug safety during pregnancy. Toavoid a possible undesirable action on the organism of mother andfetus, Mildronate is not given during pregnancy.

Breast-feeding:
Itis not known whether active substance is excreted in human milk. Ifmother needs to be treated with the drug, she has to stop breast-feeding.

Driving and using machines: The cases of Mildronate unfavorable effect on ability to drive or use machines are unknown.

Using other medicines:Please inform your doctor or pharmacist if you are taking or haverecently taken any other medicines, even those not prescribed.
Mildronatecould be combined with antianginal drugs, anticoagulants,antiagregants, antarrhythmic drugs, cardiac glycosides, diuretics etc.
Mildronatemay intensify the actions of several cardiovascular agents such as nitroglycerine, nifedipine, beta-adrenoblockers, hypotensive agents andperipheral vasodilators.

HOW TO USE MILDRONATE Usual adult daily dose – 2 to 4 capsules (500 to 1000 mg) by mouth. Itis given as a single dose in the morning or in two divided doses. Inview of a possible development of active substance exciting effect itis recommended to take in the first half of the day.
If you take more Mildronate than you should:
Nodata on Mildronate overdose are known. It is low toxic and does notcause severe side effects. If sharp changes of arterial blood pressureare observed, symptomatic therapy should be given as appropriate.
If you forget to take Mildronate:
Do not take a double dose to make up for forgotten individual doses.

POSSIBLE SIDE EFFECTS In separate cases, allergic reactions, dyspeptic disturbances,tachycardia, changes in arterial pressure, headache, agitation,weakness may occur; eosinophylia has been reported (one case reported).

Patients should discontinue usage of medicine and consult their doctor, if allergic reactions are developed.

If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.

STORING OF MILDRONATE Protect from moisture. Do not store above 25˚С.
Keep out of the reach and sight of children.
Do not use after expiratory date printed on package!
Prescription drug.