API manufacturing

«Grindeks» API manufacturing facilities ensure bulk production of substances and intermediary products as well as products scaling. 

The core technologies cover the following types of reactions:

• Substitution
• Elimination
• Addition
• Regrouping
• Specialized reactions

Typical processes for the routine production are:

• Heating / cooling (from -30° C to +250°C)
• Autoclave processes (up to 40 tam)
• Rectification; extraction
• Crystallization; sedimentation / filtration
• Distillation in vacuum
• Saturation with gases
• Freeze-drying

Manufacturing scale:

• Stainless-steel and glass lined jacketed reactors from 250° to 1,600l
• Autoclave 160l
• Centrifuges (max load 250kg)
• Rectification columns
• Vacuum and pressure filters
• Shelf and conical dryers
• Evaporation equipment (10/hr to 50l/hr)
• Freeze-drying equipment

Separate production lines and cleaning validation are used to prevent cross-contamination.